EDUCATION
Ph.D 1996-2001 Zhejiang University Plant Nutrition
B.S. 1990-1994 Shandong University Biology
WORK EXPERIENCE
2014.9-present Shandong University School of Life Sciences Assoicate Professor
2008.10-2014.8 Shandong University School of Life Sciences Instructor
2004. 2-2008.9 Emory University Winship Cancer Institute Res. Speicalist Lead
2001.9-2004.2 China Science & Technology Museum Engineer
RESEARCH INTERST
1. Cancer metastasis
2. Anti-cancer compound screening and molecular therapeutics
SELECTED PUBLICATIONS
1. S Yao, F Shi, Y Wang, X Sun, W Sun, Y Zhang, X Liu, X Liu*, L Su*. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells. Cellular Signalling. 2019;61:10-19.
2. W An, S Yao, X Sun, Z Hou, Y Liu*, L Su*, X Liu*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019 May 2;38(1):181.
3. M Li, W An, L Xu, Y Liu, L Su*, X Liu*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019 Feb 8;38(1):64.
4. X Yu#, J Ling#, X Liu, S Guo, Y Liu, X Liu, L Su*. Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells. Oncotarget. 2017 Jan 24;8(4):6691-6699.
5. Z Liu, S Chu, S Yao, Y Li, S Fan, X Sun, L Su*, X Liu*. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. Oncotarget. 2016. Oct 18;7(42):68303-68313.
6. M Zhang#, L Su#, Z Xiao, X Liu, X Liu*. Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer. Am J Cancer Res. 2016; 6(2):187-99.
7. X Liu, S Guo, X Liu, L Su*. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis. 2015; 20(11):1499-507.
8. T Li#, L Su#, Y Lei#, X Liu, Y Zhang, X Liu*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.
9. J Cui, W Sun, X Hao, M Wei, X Su, Y Zhang, L Su, X Liu*. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int. 2015; 15(1):4.
10. J Yan, N Zhong, G Liu, K Chen, X Liu, L Su*, Singhal S. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014; 5: e1316.
11. X ZHao, X Liu, L Su*. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014; 33(1):3.
12. X Liu, L Su*, X Liu. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587: 3995-4000.
13. T Li, L Su(co-first author) , N Zhong, X Hao, D Zhong, Singhal S, X Liu. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.
14. L Yang, L Su(co-first author), C Cao, L Xu, D Zhong, L Xu, X Liu. The chalcone 2'-hydroxy- 4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells. IUBMB Life. 2013; 65:533-43.
15. L Xu, L Su(co-first author) X Liu. PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells. Mol Cancer Ther. 2012; 11:2174-82.
16. G Liu, L Su* (co-first author), X Hao, N Zhong, D Zhong, Singhal S, X Liu*. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012; 16:1618-28.
17. Q Wang, W Sun, X Hao, T Li, L Su* , X Liu. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells. Cancer Cell Int. 2012; 12(1):54.
18. G Jia, L Su, Singhal S, X Liu. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol Cell Biochem. 2012;364(1):345-50.
AWARDS
1. Award of Teaching Master, Shandong University, 2012
2. Teaching Contest of Shandong University (Young Teachers), Second Award, 2012
