EDUCATION
1990.9-1994.7 Shandong University, BS in Biology
1994.9-1997.7 Shandong University, MS in Cell Biology
1997.9-2000.7 Institute of Microbiology, UCAS, PhD in Microbiology
WORK EXPERIENCE
2000.9-2002.11，Postdoctoral fellow, Peking University Health Science Center
2002.11-2003.8，Postdoctoral fellow, University of Florida
2003.9-2008.8，Postdoctoral fellow, Emory University Winship Cancer Institute
2008.10-present, Professor of Cell Biology, Shandong University School of Life Sciences,
RESEARCH INTERST
1.Apoptotic and autophagic signaling pathways in cancer cells
2.Cancer metastasis
3.Anti-cancer drug screening
SELECTED PUBLICATIONS
1.S Yao, F Shi, Y Wang, X Sun, W Sun, Y Zhang, X Liu, X Liu*, L Su*. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells. Cell Signal. 2019. pii: S0898-6568(19)30103-2.
2.W An, S Yao, X Sun, Z Hou, Y Lin*, L Su*, X Liu*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019 May 2;38(1):181.
3.M Li, W An, L Xu, Y Lin, L Su*, X Liu*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019 Feb 8;38(1):64.
4.M Zhang#, L Su#, Z Xiao, X Liu, X Liu*. Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer. Am J Cancer Res. 2016, 6(2):187-99.
5.T Li, L Su, Y Lei, X Liu, Y Zhang, X Liu*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.
6.X Liu, L Su*, X Liu*. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587:3995-4000.
7.T Li, L Su, N Zhong, X Hao, D Zhong, Singhal S, X Liu*. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.
8.L Xu, L Su, X Liu*. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012; 11(10):2174-82.
9.G Liu, L Su, X Hao, N Zhong, D Zhong, Singhal S, X Liu*. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012; 16(7):1618-28.
10.L Su, G Liu, X Hao, N Zhong, D Zhong, X Liu*, Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer. 2011; 47(16):2471-8.
11.Oh YT#, X Liu#, P Yue, S Kang, J Chen, Taunton J, Khuri FR, SY Sun.ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010; 285(53): 41310-41319.
12.X Liu, P Yue, S Chen, L Hu, Lonial S, Khuri FR, SY Sun. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007; 67 (10):4981-8.
13.X Liu, P Yue, Schonthal AH, Khuri FR, SY Sun. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006; 66(23):11115-9.
14.X Liu, P Yue, Khuri FR, SY Sun. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005; 65(20): 9169-75.
15.F Jin#, X Liu#, ZZ Hou, P Yue, Lotan R, Khuri FR, LW Chung, SY Sun. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005; 65(14):6354-63.
16.X Liu, P Yue, ZZ Zhou, Khuri FR, SY Sun. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004; 96(23): 1769-80.
17.X Liu, P Yue, Khuri FR, SY Sun. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004; 64(15): 5078-83.
