姓名：徐志刚

办公电话：86-532-58630869

电子邮箱：xuzg(AT)sdu.edu.cn

教育背景

                  起止时间                毕业院校                                               专业

本科   1995.09 - 1998.07          烟台大学               生物化学

博士   1998.09 - 2004.01          复旦大学               遗传学

工作经历

       起止时间                单位名称                                                   专业技术职务

2004.01–2004.12       中国国家人类基因组南方研究中心     科研人员

2005.01–2005.09       美国哈佛大学医学院             博士后

2005.10–2009.05       美国斯坦福大学医学院            博士后

2009.05–现在    山东老员工命科学学院             教授

科研方向

1. 听纤毛发育及维持分子机制

2. 听觉转导分子机制

3. 耳聋发生分子机制

代表性论文（*通讯作者）

1. Wang X, Liu S, Cheng Q, Qu C, Ren R, Du H, Li N, Yan K, Wang Y, Xiong W*, Xu Z*. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. J Neurosci. 2023;43(18):3219-3231. (Featured article)

2. Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM*, Sun JP*, Xu ZG*. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Adv Sci (Weinh). 2023;10(16):e2205993.

3. Wang H, Du H, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z*, Lu Q*. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun. 2023;14(1):1657.

4. Ren R, Xing H, Wang X, Du H, Wang Y, Xu Z*. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Hum Mol Genet. 2023;32(10):1622-1633. (Cover story)

5. Wang Y, Zhang C, Peng W, Du H, Xi Y, Xu Z*. RBM24 is required for mouse hair cell development through regulating pre-mRNA alternative splicing and mRNA stability. J Cell Physiol. 2023;238(5):1095-1110.

6. Zhai X, Du H, Shen Y, Zhang X, Chen Z, Wang Y, Xu Z*. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. J Cell Sci. 2022;135(16):jcs259912.

7. Yan K, Zong W, Du H, Zhai X, Ren R, Liu S, Xiong W, Wang Y, Xu Z*. BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells. J Cell Physiol. 2022;237:774-788.

8. Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun J, Yang J, Xiong W*, Xu Z*. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J., 2020;34:1136-1149.

9. Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R*, Xu Z*. Loss of CIB2 causes profound hearing loss and abolishes mechanoelectrical transduction in mice. Front. Mol. Neurosci., 2017;10:401.

10. Cheng X, Shao M, Li J, Wang Y, Qi J, Xu Z*, Shi D*. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nat. Commun. 2017;8:1353.

论著

1. Xu Z, Peng AW, Xiong W. Hair bundles - Development, maintenance, and function. 2021, Lausanne: Frontiers Media SA. ISBN 978-2-88971-968-6.

2. Xiong W, Xu Z. Mechanotransduction of the hair cell. 2018, Springer. ISBN: 9789811085574 (online) 9789811085567 (print).